![]() ![]() Īccording to the latest available data at the Italian National Institute of Statistics (ISTAT), the 2015 suicide rate in Italy was 8.4 per 100 000 inhabitants. Suicide can occur throughout the lifespan, but was the second leading cause of death among 15–29-year-olds globally in 2016. Each suicide is a tragedy that affects families, communities, and entire countries and can have long-lasting effects on the people left behind. Over 700 000 people take their own life every year throughout the world, and many more attempt suicide. Our study identified several potential genetic links with suicide in a cohort of Italians and supports a relationship between specific genetic variants and suicidal behaviour in this population.įorensic sciences, forensic genetics, suicide, MAOA, HTR2A, SCN8A, NOS3 Introduction In addition, four missense mutations were identified in four different genes: Monoamine Oxidase A ( MAOA), 5-Hydroxytryptamine Receptor 2 A ( HTR2A), Sodium Voltage-Gated Channel Alpha Subunit 8 ( SCN8A), and Nitric Oxide Synthase 3 ( NOS3). In this study, we identified 19 gene variants that were present at significantly lower frequencies in our Italian cohort than in the general population. Next-generation sequencing was used to compare these gene sequences with those from a large, normal population. DNA samples were obtained from tissues or blood, and 22 genes from multiple neurobiological pathways previously shown to be associated with the pathogenesis of suicide were analysed. This cohort included 86 men and 25 women. We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide had been declared in court in Florence, Italy between 20. ![]() However, data on suicide in the Italian population are scarce. Many studies have examined the genetic contribution to suicide. ![]()
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